In pathogenesis of periodontal diseases, the imbalance of reactive oxygen species is closely related to the disorder in the cells and may cause changes in cellular metabolism and mitochondrial activity, which is implicated in oxidative stress status or even in cell death. Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. A conclusão do presente estudo é que o extrato apresenta ação bacteriostática e antiaderente, contudo, a cinética bactericida precisa de mais estudos. O resultado para a CIM foi a diluição 1:16 (3,125 x 10-2 g/mL), enquanto a CIMA foi a diluição 1:128 (3,90625 x 10-3 g/mL) e a CB apresentou crescimento bacteriano 2 horas após o contato do extrato com a bactéria. leptophloeos determinação da concentração inibitória mínima de aderência (CIMA) e determinação da cinética bactericida (CB) com cultivo de S. Após a confecção do extrato, foram executados 3 experimentos: determinação da concentração inibitória mínima (CIM) do extrato das cascas do caule de C. Com isso, o objetivo da pesquisa é investigar in vitro a ação antimicrobiana, bactericida e antiaderente do extrato hidroetanólico das cascas do caule de Commiphora leptophloeos (Mart.) J.B. A planta medicinal Commiphora leptophloeos (Mart.) JB Gillett, popularmente conhecida como imburana-de-espinho, encontrada no bioma Caatinga, tem sido pesquisada para esse fim. However, PLA presented significantly higher collagen maturation and protective effect against bone resorption than MAT.ĭevido aos altos índices de infecções bucais, em paralelo à necessidade de novos métodos antimicrobianos, os fitoterápicos têm sido a escolha com ação efetiva e de menor toxicidade, quando vigorosamente padronizados. Conclusions: Combine MAT or PLA with SRP to treat EP presented additional antimi-crobial and anti-inflammatory effects when compared to SRP. Group PLA presented significantly higher OPG than Group SRP (7 days) and significantly lower RANKL than groups MAT and SRP (15 days). Group MAT had significantly higher percentage of immature collagen fibers than groups SRP and PLA (15 days). Group PLA had significantly lower BL than Group MAT (7 days). Results: Groups MAT and PLA had significantly lower number of CFU than Group SRP (15 days). It was evaluated colony-forming units (CFU), bone loss (BL), percentage of mature and immature collagen fibers, TRAP, RANKL and OPG (p <0.05). Euthanasia was performed after 7, 15 and 30 days (n=8). After 7 days, animals were randomly distributed in groups: SRP-SRP and irrigation with saline MAT-SRP and irrigation with MAT solution and PLA-SRP and irrigation with PLA solution. This improved the clinical and microbiological parameters.Īim: To evaluate subgingival irrigation with Matricaria recutita (MAT) and Plantago major (PLA) adjunct to scaling and root planing (SRP) on treatment of experimental periodontitis (EP). This systematic review and meta-analysis indicated that Curcuma is an effective product when applied as adjunct therapy for PD treatment. In comparison with the control group, Curcuma was associated with a reduction in pocket depth after 90 days of treatment (mean deviation: 0.48 95% confidence interval: 0.89–0.08). Quantitative analysis of different clinical parameters was described. Twelve studies were included in the review and 11 in the meta-analysis. The main eligibility criteria were randomized clinical trials in humans published in the English language. We searched databases using specific keywords and Boolean operators and systematically conducted the extraction and analysis according to the PROSPERO (CRD42019145691) database. This systematic review aimed to summarize and evaluate whether Curcuma can contribute to PD treatment when applied as an adjunct to the standard scaling and root planing therapy. Anti-infective herbal products, such as Curcuma, have been added as adjuvant therapy to prolong periodontal treatment outcomes. However, the instrumentation techniques can fail to completely eliminate calculus, particularly in higher grade and progression rated PD cases, and the continuing efficient removal of the biofilm by the patient can limit the long-term response of this treatment. Scaling and root planing, associated with adequate plaque control, are considered the gold standard treatments for this disease. Owing to its multifactorial etiology, treatment and maintenance are challenging. Periodontal disease (PD) is the second most prevalent buccal infectious condition in adults.
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